Bacteriophage Publications - Intralytix, Inc.

safety by nature depiction

safety by nature depiction

intralytix bacteriophage and Technology

intralytix bacteriophage and Food Safety

intralytix bacteriophage and Environmental Sanitation

Environmental Sanitation

intralytix bacteriophage and Veterinary Applications

Veterinary Applications

intralytix bacteriophage and Human Therapeutics

Human Therapeutics

intralytix bacteriophage and Dietary Supplements / Nutraceuticals

Dietary Supplements / Nutraceuticals

Scientific Publications

Knowledge Discovery

Targets

Food Categories

Food Products

Rigorous Science

Our commitment to scientific excellence is reflected in an extensive history of peer-reviewed research, exploring the diverse applications of bacteriophage technology.

A Bacteriophage Cocktail Targeting Yersinia pestis Provides Strong Post-Exposure Protection in a Rat Pneumonic Plague Model

Paul B. Kilgore, Jian Sha, Emily K. Hendrix, Blake H. Neil, William S. Lawrence, Jennifer E. Peel, Lauren Hittle, Joelle Woolston, Alexander Sulakvelidze, Jennifer A. Schwartz, Ashok K. Chopra.

Microbiology Spectrum

Safety and Tolerability of ShigActive™, a Shigella spp. Targeting Bacteriophage Preparation, in a Phase 1 Randomized, Double-Blind, Controlled Clinical Trial

Wilbur H. Chen, Joelle Woolston, Silvia Grant-Beurmann, Courtney K. Robinson, Garima Bansal, Joseph Nkeze, Jasnehta Permala-Booth, Claire M. Fraser, Sharon M. Tennant, Mallory C. Shriver, Marcela F. Pasetti, Yuanyuan Liang, Karen L. Kotloff, Alexander Sulakvelidze, and Jennifer A. Schwartz

Biocontrol of Two Escherichia coli O157:H7 Strains and a Nonpathogenic Surrogate E. coli in Wheat Grains and Wheat Milling Operations Using a Lytic Bacteriophage Cocktail

Vikram, A., McCarty, K., Callahan, M.T., Sullivan, J., Sulakvelidze, A.

Comparison of Crohn’s disease-associated adherent-invasive Escherichia coli (AIEC) from France and Hong Kong: results from the Pacific study

Chevarin C, Xu Z, Martin L, Robin F, Beyrouthy R, Colombel J, Sulakvelidze A, Ng S, Bonnet R, Buisson A, Barnich N

ECOPHAGE: Combating Antimicrobial Resistance Using Bacteriophages for Eco-Sustainable Agriculture and Food Systems

García P, Tabla R, Anany H, Bastias R, Brøndsted L, Casado S, Cifuentes P, Deaton J, Denes T, Islam M, Lavigne R, Moreno-Switt A, Nakayama N, Muñoz Madero C, Sulakvelidze A, Svircev A, Wagemans J, Biosca E, Rivera D

Evaluation of a Preharvest Bacteriophage Therapy for Control of Salmonella within Bovine Peripheral Lymph Nodes

Wottlin LR, Edrington TS, Brown TR, Zook CA, Sulakvelidze A, Droleskey R, Genovese KJ, Nisbet DJ.

Journal of Food Protection

A Bacteriophage Cocktail Significantly Reduces Listeria monocytogenes without Deleterious Impact on the Commensal Gut Microbiota under Simulated Gastrointestinal Conditions

Jakobsen RR, Trinh JT, Bomholtz L, Brok-Lauridsen SK, Sulakvelidze A, Nielsen DS.

Bacteriophages improve survival and metamorphosis of larval Pacific oysters (Crassostrea gigas) exposed to Vibrio coralliilyticus strain RE98

Madison D, Richards G, Sulakvelidze A, Langdon C

Phage biocontrol for reducing bacterial foodborne pathogens in produce and other foods

Vikram A, Callahan M, Woolston J, Sharma M, Sulakvelidze A

Current Opinion in Biotechnology

Prophylactic Administration of a Bacteriophage Cocktail Is Safe and Effective in Reducing Salmonella enterica Serovar Typhimurium Burden in Vivo

Lamy-Besnier Q, Chaffringeon L, Lourenço M, Payne R, Trinh J, Schwartz J, Sulakvelidze A, Debarbieux L

Microbiology Spectrum

Bacteriophages against Vibrio coralliilyticus and Vibrio tubiashii: Isolation, Characterization, and Remediation of Larval Oyster Mortalities

Richards GP, Watson MA, Madison D, Soffer N, Needleman DS, Soroka DS, Uknalis J, Baranzoni GM, Church KM, Polson SW, Elston R, Langdon C, Sulakvelidze A.

Applied and Environmental Microbiology

Phage Biocontrol Applications in Food Production and Processing

Amit Vikram, Joelle Woolston and Alexander Sulakvelidze

Current Issues in Molecular Biology

Phage biocontrol improves food safety by significantly reducing both the concentration and occurrence of Escherichia coli O157:H7 in various foods

Vikram, A., Tokman, J., Woolston, J., and Sulakvelidze, A.

Journal of Food Protection

Employing list-shield bacteriophage as a bio-control intervention for Listeria monocytogenes from raw beef surface and maintain meat quality during refrigeration storage

Ishaq, A., P. D. Ebner, Q. A. Syed, and H. Ubaid ur Rahman.

LWT - Food Science and Technology

Treatment of fresh produce with a Salmonella-targeted bacteriophage cocktail is compatible with chlorine or peracetic acid and more consistently preserves the microbial community on produce.

Moye Z, Rajanna C, Tokman J, Fanelli B, Hasan N, Marek P, Senecal A, Sulakvelidze A.

Journal of Food Safety

A Bacteriophage Cocktail Eliminates Salmonella Typhimurium from the Human Colonic Microbiome while Preserving Cytokine Signaling and Preventing Attachment to and Invasion of Human Cells by Salmonella In Vitro

Moye ZD, Woolston J, Abbeele PVD, Duysburgh C, Verstrepen L, Das CR, Marzorati M, Sulakvelidze A.

Journal of Food Protection

SalmoFresh™ effectiveness in controlling Salmonella on romaine lettuce, mung bean sprouts and seeds.

Zhang, X., Niu, Y.D., Nan, Y., Stanford, K., Holley, R., McAllister, T., and Narváez-Bravo, C.

International Journal of Food Microbiology

Bacteriophage Applications for Food Production and Processing

Moye Z, Woolston J, Sulakvelidze A

A bacteriophage cocktail targeting Escherichia coli reduces E. coli in simulated gut conditions, while preserving a non-targeted representative commensal normal microbiota

Tomasz C., Nitzan S., Alexander S., Dennis S.N.

Applicability of commercial phage-based products against Listeria monocytogenes for improvement of food safety in Spanish dry-cured ham and food contact surfaces.

Gutiérrez, D., Rodríguez-Rubio, L., Fernández, L., Martínez, B., Rodríguez, A., and García, P.

Effectiveness of a phage cocktail as a biocontrol agent against L. monocytogenes biofilms.

Sadekuzzaman, M., S. Yang, M. F. R. Mizan, H.-S. Kim, and S.-D. Ha.

Bacteriophage preparation lytic for Shigella significantly reduces Shigella sonnei contamination in various foods.

Soffer N, Woolston J, Li M, Das C, Sulakvelidze A.

Reduction of Listeria monocytogenes on chicken breasts by combined treatment with UV-C light and bacteriophage ListShield.

Yang, S., Sadekuzzaman, M., and Ha, S.-D.

Survival of Salmonella Newport on Whole and Fresh-Cut Cucumbers Treated with Lytic Bacteriophages.

Sharma, M., Dashiell, G., Handy, E.T., East, C., Reynnells, R., White, C., Nyarko, E., Micallef, S., Hashem, F., and Millner, P.D.

Journal of Food Protection

Effects of Salmonella bacteriophage, nisin and potassium sorbate and their combination on safety and shelf life of fresh chilled pork.

Wang, C., Yang, J., Zhu, X., Lu, Y., Xue, Y., and Lu, Z.

Reduction of Salmonella on chicken breast fillets stored under aerobic or modified atmosphere packaging by the application of lytic bacteriophage preparation SalmoFresh™

Sukumaran, A.T., Nannapaneni, R., Kiess, A., and Sharma, C.S.

Poultry Science

Bacteriophages safely reduce Salmonella contamination in pet food and raw pet food ingredients.

Soffer, N., Abuladze, T., Woolston, J., Li, M., Hanna, L.F., Heyse, S., Charbonneau, D., and Sulakvelidze, A.

Effect of a bacteriophage cocktail in combination with modified atmosphere packaging in controlling Listeria monocytogenes on fresh-cut spinach

Boyacioglu O, Sulakvelidze A, Sharma M, Goktepe I

Irish Journal of Agricultural and Food Research

Bacteriophage Cocktail for Biocontrol of Salmonella in Dried Pet Food.

Heyse, S., Hanna, L.F., Woolston, J., Sulakvelidze, A., and Charbonneau, D.

Journal of Food Protection

Salmonella Phages and Prophages: Genomics, Taxonomy, and Applied Aspects

Switt A, Sulakvelidze A, Wiedmann M, Kropinski A, Wishart D, Poppe C, Liang Y

Methods in Molecular Biology

Bacteriophage administration significantly reduces Shigella colonization and shedding by Shigella-challenged mice without deleterious side effects and distortions in the gut microbiota

Mai V, Ukhanova M, Reinhard MK, Li M, Sulakvelidze A.

Bacteriophage cocktail significantly reduces or eliminates Listeria monocytogenes contamination on lettuce, apples, cheese, smoked salmon and frozen foods

Perera, M., Abuladze, T., Li M., Woolston, J., and Sulakvelidze, A.

Food Microbiology

Reduction of Salmonella on chicken meat and chicken skin by combined or sequential application of lytic bacteriophage with chemical antimicrobials.

Sukumaran, A.T., Nannapaneni, R., Kiess, A., and Sharma, C.S.

International Journal of Food Microbiology

Efficacy of Lytic Bacteriophage Preparation in Reducing Salmonella In Vitro, on Turkey Breast Cutlets, and on Ground Turkey.

Sharma, C.S., Dhakal, J., and Nannapaneni, R.

Journal of Food Protection

Evaluation of consumers’ perception and willingness to pay for bacteriophage treated fresh produce

Naanwaab C, Yeboah O, Ofori Kyei F, Sulakvelidze A, Goktepe I

Lytic bacteriophages reduce Escherichia coli O157:H7 on fresh cut lettuce introduced through cross-contamination.

Ferguson, S., Roberts, C., Handy, E., and Sharma, M.

Biocontrol of Escherichia coli O157:H7 on fresh-cut leafy greens.

Boyacioglu, O., Sharma, M., Sulakvelidze, A., and Goktepe, I.

Using lytic bacteriophages to eliminate or significantly reduce contamination of food by foodborne bacterial pathogens

Journal of the Science of Food and Agriculture

Additive Approach for Inactivation of Escherichia coli O157:H7, Salmonella, and Shigella spp. on Contaminated Fresh Fruits and Vegetables Using Bacteriophage Cocktail and Produce Wash.

Magnone, J.P., Marek, P.J., Sulakvelidze, A., and Senecal, A.G.

Journal of Food Protection

A Yersinia pestis-specific, lytic phage preparation significantly reduces viable Y. pestis on various hard surfaces experimentally contaminated with the bacterium

Rashid M, Revazishvili T, Dean T, Butani A, Verratti K, Bishop-Lilly K, Sozhamannan S, Sulakvelidze A, Rajanna C

Bacteriophage cocktail significantly reduces Escherichia coli O157:H7 contamination of lettuce and beef, but does not protect against recontamination.

Carter, C.D., Parks, A., Abuladze, T., Li, M., Woolston, J., Magnone, J., Senecal, A., Kropinski, A.M., and Sulakvelidze, A.

Bacteriophage Administration Reduces the Concentration of Listeria monocytogenes in the Gastrointestinal Tract and Its Translocation to Spleen and Liver in Experimentally Infected Mice.

Mai, V., Ukhanova, M., Visone, L., Abuladze, T., and Sulakvelidze, A.

International Journal of Microbiology

Bacteriophage Therapy for Control of Necrotic Enteritis of Broiler Chickens Experimentally Infected with Clostridium perfringens

Miller R, Skinner J, Sulakvelidze A, Mathis G, Hofacre C

Effectiveness of bacteriophages in reducing Escherichia coli O157:H7 on fresh-cut cantaloupes and lettuce.

Sharma, M., Patel, J.R., Conway, W.S., Ferguson, S., and Sulakvelidze, A.

Journal of Food Protection

Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial

Rhoads D, Wolcott R, Kuskowski M, Wolcott B, Ward L, Sulakvelidze A

Journal of Wound Care

Bacteriophages reduce experimental contamination of hard surfaces, tomato, spinach, broccoli, and ground beef by Escherichia coli O157:H7

Abuladze, T., Li, M., Menetrez, M.Y., Dean, T., Senecal, A., and Sulakvelidze, A.

Applied and Environmental Microbiology

Phage therapy: an attractive option for dealing with antibiotic-resistant bacterial infections

Drug Discovery Today

The use of a novel biodegradable preparation capable of the sustained release of bacteriophages and ciprofloxacin, in the complex treatment of multidrug-resistant Staphylococcus aureus-infected local radiation injuries caused by exposure to Sr90

Jikia D, Chkhaidze N, Imedashvili E, Mgaloblishvili I, Tsitlanadze G, Katsarava R, Glenn Morris J, Sulakvelidze A

Clinical and Experimental Dermatology

Optimizing Concentration and Timing of a Phage Spray Application To Reduce Listeria monocytogenes on Honeydew Melon Tissue.

Leverentz, B., Conway, W.S., Janisiewicz, W., and Camp, M.J.

Journal of Food Protection

Biocontrol of Listeria monocytogenes on Fresh-Cut Produce by Treatment with Lytic Bacteriophages and a Bacteriocin.

Leverentz, B., Conway, W.S., Camp, M.J., Janisiewicz, W.J., Abuladze, T., Yang, M., Saftner, R., and Sulakvelidze, A.

Applied and Environmental Microbiology

A novel sustained‐release matrix based on biodegradable poly(ester amide)s and impregnated with bacteriophages and an antibiotic shows promise in management of infected venous stasis ulcers and other poorly healing wounds

Markoishvili K, Tsitlanadze G, Katsarava R, Glenn J, Morris Jr. MD, Sulakvelidze A

International Journal of Dermatology

Bacteriophage Therapy

Sulakvelidze A, Alavidze Z, Morris J

Antimicrobial Agents and Chemotherapy

Bacteriophages as therapeutic agents

Sulakvelidze A, Morris J

Annals of Medicine

Examination of Bacteriophage as a Biocontrol Method for Salmonella on Fresh-Cut Fruit: A Model Study

Leverentz B, Conway W, Alavidze Z, Janisiewicz W, Fuchs Y, Camp M, Chighladze E, Sulakvelidze A

Journal of Food Protection